JamisJockey
Hasn't stopped the fed.gov from persecuting drug posession in states that have legalized it
I do not know of any of the cases you speak of that have challenged the prosecution on the grounds of jurisdiction where the federal government had no jurisdiction.
Most people are "blissfully" unaware of the fact that jurisdiction is required, and that no one is required to tell them that before they enter a guilty plea, or their "defense" is defeated on other grounds.
Here are some SCOTUS cases where jurisdiction (state and federal) was challenged:
Reily v. Lamar, 2 Cranch 344 (1804)
United States v. Bevans, 16 U.S. (3 Wheat.) 336 (1818)
I would suggest reading Adams v. United States for the most straightforward rendering.
New Orleans v. United States, 35 U.S. (10 Pet.) 662 (1836)
Pollard v. Hagan, 44 U.S. (3 How.) 212 (1845)
United States v. Erie Ry. Co., 106 U.S. 327, 333, 1 S.Ct. 223 (1882)
Fort Leavenworth R. Co. v. Lowe, 114 U.S. 525, 5 S.Ct. 995 (1885)
Chicago, R. I. & P. Ry. Co. v. McGlinn, 114 U.S. 542, 5 S.Ct. 1005 (1885)
Benson v. United States, 146 U.S. 325, 13 S.Ct. 60 (1892)
Palmer v. Barrett, 162 U.S. 399, 16 S.Ct. 837 (1896)
Camfield v. United States, 167 U.S. 518, 17 S.Ct. 864 (1897)
Hamburg American Steamship Co. v. Grube, 196 U.S. 407, 25 S.Ct. 352 (1905)
Battle v. United States, 209 U.S. 36, 28 S.Ct. 422 (1908)
Western Union Telegraph Co. v. Chiles, 214 U.S. 274, 29 S.Ct. 613 (1909)
Holt v. United States, 218 U.S. 245, 31 S.Ct. 2 (1910)
United States v. Grimaud, 220 U.S. 506, 31 S.Ct. 480 (1911)
Western Union Telegraph Co. v. Brown, 234 U.S. 542, 34 S.Ct. 955 (1914)
Omaechevarria v. State of Idaho, 246 U.S. 343, 346, 38 S.Ct. 323 (1918)
Rodman v. Pothier, 264 U.S. 399, 44 S.Ct. 360 (1924)
Colorado v. Toll, 268 U.S. 228, 45 S.Ct. 505 (1925)
Arlington Hotel Co. v. Fant, 278 U.S. 439, 49 S.Ct. 227 (1929)
United States v. Unzeuta, 281 U.S. 138, 50 S.Ct. 284 (1930)
Surplus Trading Co. v. Cook, 281 U.S. 647, 50 S.Ct. 455 (1930)
Standard Oil Co. v. California, 291 U.S. 242, 54 S.Ct. 381 (1934)
Murray v. Joe Gerrick & Co., 291 U.S. 315, 54 S.Ct. 432 (1934)
James v. Dravo Contracting Co., 302 U.S. 134, 58 S.Ct. 208 (1937)
Silas Mason Co. v. Tax Commission of State of Washington, 302 U.S. 186, 58 S.Ct. 233 (1937)
Atkinson v. State Tax Commission of Oregon, 303 U.S. 20, 58 S.Ct. 419 (1938)
Collins v. Yosemite Park & Curry Co., 304 U.S. 518, 58 S.Ct. 1009 (1938)
Bowen v. Johnston, 306 U.S. 19, 59 S.Ct. 442 (1939)
James Stewart & Co. v. Sadrakula, 309 U.S. 94, 60 S.Ct. 431 (1940)
Penn Dairies v. Milk Control Comm. of Pennsylvania, 318 U.S. 261, 63 S.Ct. 617 (1943)
Pacific Coast Dairy v. Dept. of Agriculture of California, 318 U.S. 285, 63 S.Ct. 628 (1943)
Adams v. United States, 319 U.S. 312, 63 S.Ct. 1122 (1943)
Johnson v. Yellow Cab Transit Co., 321 U.S. 383, 64 S.Ct. 622 (1944)
Wilson v. Cook, 327 U.S. 474, 66 S.Ct. 663 (1946)
S.R.A. v. Minnesota, 327 U.S. 558, 66 S.Ct. 749 (1946)
Howard v. Commissioners of Sinking Fund of City of Louisville, 344 U.S. 624, 73 S.Ct. 465 (1953)
Offutt Housing Co. v. County of Sarpy, 351 U.S. 253, 76 S.Ct. 814 (1956)
Paul v. United States, 371 U.S. 245, 83 S.Ct. 426 (1963)
Humble Pipe Line Co. v. Waggonner, 376 U.S. 369, 84 S.Ct. 857 (1964)
United States v. State Tax Commission of Mississippi, 412 U.S. 363, 93 S.Ct. 2183 (1973)
McClanahan v. State Tax Comm. of Arizona, 411 U.S. 164, 93 S.Ct. 1257 (1973)
California Coastal Comm. v. Granite Rock Company, 480 U.S. 572, 107 S.Ct. 1419 (1987)